General approach

The molecular motors kinesin, myosin, and dynein play an important role in organizing the inner life of eukaryotic cells. They interact with a range of co-factors to assemble into motile transport particles and mediate subcellular localization of cargos like proteins, mRNAs, vesicles, and organelles.

We use a combination of X-ray crystallography, biophysical and biochemical approaches to understand mechanisms of motor-cargo interaction and the assembly of active cargo complexes.